Here are two great sounding, yet simple circuits from Run Off Groove. The Big Daddy uses a JFET gain stage to push a 386 chip, while the Grace uses a JFET buffer in front of the 386 for added sparkle. Parts-wise, there's not a lot different between the two, so I've only drawn up one board. Schematics, sound clips, and more info can be found on the ROG site.
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To populate the board for the Grace, omit the 2.2uF capacitor, jumper the 15k resistor, and replace the 2.2k resistor with a 15k one. See below:
